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Colliding Crises: Youth Mental Health and Nicotine Use

Many young people turn to nicotine to alleviate stress, anxiety, and depression, but it may be making them feel worse

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Two health crises among youth — a mental health crisis and a vaping epidemic — pose increasing threats to a generation of young people. They are also linked in ways many may not realize, according to a body of peer-reviewed studies.

Both crises have intensified during the COVID-19 pandemic. Even before the pandemic, 70% of young people said anxiety and depression were a major problem among peers in their community, according to a Pew Research Center report. Since then, the problem has gotten worse, as the prevalence of depression and anxiety symptoms in youth has doubled compared to before the pandemic. Alongside this mental health crisis, youth e-cigarette use — driven by products that quickly deliver highly-addictive nicotine — has remained at epidemic levels, with one in five high school students vaping in 2020, according to the National Youth Tobacco Survey. In the time since that survey, national e-cigarette sales have risen to record highs and the risks of vaping have become more apparent, as evidence shows it can harm lung health and may put users at greater risk of contracting COVID-19.

While it is well known that nicotine harms developing brains, including by making young people more susceptible to addiction, lesser known are the worrying connections between nicotine and mental health. Though nicotine has not been found to directly cause mental health conditions and more research is needed, numerous peer-reviewed studies reveal troubling links, including clearly established research that shows nicotine can worsen symptoms of depression and anxiety.

Concerned girl on laptop
While it is well known that nicotine harms developing brains, including by making young people more susceptible to addiction, lesser known are the worrying connections between nicotine and mental health.

Research shows several connections between nicotine and mental health:

  • Vaping nicotine can intensify symptoms of depression and anxiety and increase stress levels.
  • Current e-cigarette users have double the odds of having a diagnosis of depression compared to those who have never vaped, according to a 2019 JAMA study of nearly 30,000 current e-cigarette users. Frequent vaping is tied to even higher odds (2.4x) of having a diagnosis of depression compared to never users.
  • Using e-cigarettes can worsen symptoms of depression, based on the results of a study of nearly 2,500 ninth graders who had never previously used e-cigarettes or combustible tobacco.
  • Using e-cigarettes at a higher frequency was associated with higher depressive symptoms — including feeling sad or having crying spells — a year later.
  • Current e-cigarette users had 1.67 times higher odds and former e-cigarette users had 1.52 times higher odds of reporting at least 1 day of poor mental health in the past month compared to never users.
  • Trace metals found in vape liquid may play a role in the potential link between vaping and depression.
  • Vaping is significantly associated with higher levels of ADHD symptoms, based on a 2019 study of college students. Using e-cigarettes as an adult also had nearly twice the odds of association with cognitive complaints — having serious difficulty concentrating, remembering, or making decisions — compared to those who had never used e-cigarettes.

Many misinterpret the effects of tobacco products as a stress reliever. Indeed, Truth Initiative surveys show a large majority of young people who have used e-cigarettes started vaping to lessen feelings of stress, anxiety, or depression, and many continue vaping to cope with these feelings. Though they may be looking to nicotine for relief, many young people are unaware that vaping may make their symptoms worse.

The common misconception that nicotine relieves stress, anxiety, and depression, may be rooted in the cycle of nicotine withdrawal. Irritability, anxiety, and depression are some of the symptoms of nicotine withdrawal, and using nicotine relieves these symptoms temporarily. It’s critical to recognize that the cycle of nicotine withdrawal, subsequent nicotine use, and alleviation of symptoms all starts with nicotine addiction in the first place. [See side bar “The illusion of nicotine as a stress-reliever” below]. In addition, the tobacco industry has invested significant resources in marketing that connects tobacco use with mental well-being, stress-relief, relaxation, and pleasure. [See side bar “How Big Tobacco has linked nicotine and mental health”]. Given these two factors – the cycle of nicotine withdrawal combined with tobacco industry marketing – it’s no wonder that people have misconceptions about the role nicotine plays in mental well-being.

Published research on nicotine and mental health, combined with Truth Initiative survey data, point to an urgent need to increase awareness of the connections between youth vaping and mental well-being.

Mental Health and COVID-19

Before the COVID-19 pandemic, 70% of young people said anxiety and depression were a major problem among people their age in the community they live in, according to a 2019 report from Pew Research Center. Since then, the problem has gotten worse:

Depression and anxiety are up:


Does vaping cause anxiety and depression?

Truth Initiative surveys reveal that many young people cite feelings of stress, anxiety, or depression as reasons they start and continue vaping.

  • Overwhelming majority started vaping to decrease stress, anxiety, or depression: 81% who had used e-cigarettes said they started vaping to decrease stress, anxiety, or depression, according to an August 2021 survey of 1,000 people between ages 15 and 24.
  • More than half of vapers use e-cigarettes to cope: 50.3% of frequent vapers – those who vaped 20 or more days in the past month – reported that they need to vape to cope with stress or anxiety, according to Truth Initiative continuous tracking data from June 2021. In a separate study, when respondents were asked about the advantages of e-cigarette use, one of the most frequently listed advantages was “relaxation and stress relief.”
  • 78% of those who vaped before COVID-19 are vaping either the same or more during the pandemic. As many young people return to in-person learning, 70% report that they anticipate seeing young people vape at similar or higher rates as they go back to school.
  • Many tobacco users believe smoking reduces stress or anxiety. (See sidebar “The illusion of nicotine as a stress-reliever,”).

The illusion of nicotine as a stress-reliever

Many tobacco users believe tobacco products can relieve stress or anxiety. They might be interpreting the ability of the products to curb the symptoms of nicotine withdrawal as a beneficial effect on mental health, according to research on the effects of quitting smoking on mental health published in 2014. According to the paper, smokers experience irritability, anxiety, and depression when they have not smoked for a while, feelings which are relieved by smoking. The cycle of symptoms followed by relief from smoking can create the perception that smoking has psychological benefits.


Does vaping make anxiety and depression worse?

While young people may use e-cigarettes as a coping mechanism, they aren’t always aware of the negative role e-cigarette’s primary component — nicotine — can play in mental health. According to Truth Initiative Continuous Tracking Online (CTO) survey findings, most vapers are unaware of the mental health effects of vaping: only 44% of frequent vapers agreed that vaping can worsen anxiety and irritability, compared to 61% of those who don’t vape, according to data collected in June 2021.

More than twice as many frequent vapers (45%) agreed that it is OK to vape for stress relief compared to non-vapers (20%). Similar patterns exist for survey respondents with any past 30-day use of e-cigarettes. The results suggest that, aside from not knowing that vaping can exacerbate mental health concerns, e-cigarette users are instead using them to cope with anxiety and stress, potentially worsening mental health in the long term.

Concerned girl on the beach
Preventing the use of nicotine and helping those addicted quit is critical to helping to ensure today’s young adults are best equipped for the future.


Does quitting vaping help with depression and anxiety?

Quitting smoking is linked with lower levels of anxiety, depression, and stress, as well as improved positive mood and quality of life compared with continuing to smoke, according to a 2014 meta-analysis of 26 studies about smoking and mental health published in the British Medical Journal.

Similarly, there is emerging evidence of a link between quitting vaping and improvements in mental health symptoms. Truth Initiative survey data show support for this link between quitting nicotine-containing e-cigarettes and improved mental health outcomes.

  • 90% of those who quit said they felt less stressed, anxious, or depressed
  • 47% of respondents who quit vaping reported that when they quit vaping they felt more in control
  • 78% of respondents who reported ever vaping but had not quit said they would feel better about themselves if they quit vaping

Previous Truth Initiative research published in Preventive Medicine Reports show high interest in quitting among young people. A majority of current young e-cigarette users surveyed say they intend to quit, with one-third reporting a past-year quit attempt and 15% aiming to quit in the next month.

Truth Initiative’s This is Quitting® (TIQ), the first-of-its-kind program from truth to help young people quit vaping, has helped more than 370,000 youth and young adults on their journey to quit vaping. Teens and young adults can text “DITCHVAPE” to 88709 and get immediate help. Parents of young people who vape can get support at

How Big Tobacco has linked nicotine and mental health

The tobacco industry has invested significant resources to connect tobacco with mental well-being, including giving away cigarettes to psychiatric facilities, supporting research that positions cigarettes as a way to self-medicate, and using stress relief themes in marketing. One prominent theme used in their tobacco advertising is that “smoking can help solve some personal and emotional problems by relieving stress and promoting relaxation,” according to the National Cancer Institute’s 2008 report on the role of media in tobacco use.

This theme can be seen in many tobacco ads, from early Camel ads that picture people relaxing with a cigarette which reads: “It’s a psychological fact, pleasure helps your disposition. For more pure pleasure — have a Camel,” to the long-running Newport marketing campaign featuring the tagline “Pleasure” and images that associate cigarettes with care-free fun. Many e-cigarette brands are now tapping into themes of stress relief and mental well-being as well, including the popular disposable e-cigarette brand Puff Bar, which during the pandemic marketed its product as a way to “stay sane,” advertising it as “the perfect escape from back-to-back zoom calls, parental texts, and WFH stress.”


The associations between youth vaping nicotine and mental health concerns add to the urgency to regulate and reduce youth access to e-cigarette products. As young people continue to weather the COVID-19 pandemic and cope with its attendant stressors on mental well-being, we must work to create a supportive environment that reduces the availability of products that exacerbate symptoms of depression and anxiety. Preventing the use of nicotine and helping those addicted quit is critical to helping to ensure today’s young adults are best equipped for the future.

Policymakers and regulators must take steps to reduce the use of e-cigarettes, including:

  • Removing all flavored products: The FDA must act to remove from the market all non-tobacco flavors – including menthol – from all tobacco products, including cigarettes, e-cigarettes, little cigars, cigarillos, cigars, smokeless tobacco, and hookah. Federal actions to date to limit the marketing of e-cigarettes, including removing some pod-type flavored e-cigarette products, have proven insufficient to significantly reduce the alarming number of young people who use e-cigarettes.
  • Restrict nicotine levels: The FDA should limit nicotine levels of e-cigarettes by capping nicotine strength as is done in the EU and Canada. Truth Initiative supports restricting not only nicotine levels, but also the mechanism by which nicotine is delivered (e.g. restrictions on levels of nicotine salts), to reduce the amount of nicotine e-cigarettes deliver to the body. These restrictions will help reduce the addictiveness of the products.
  • Ensure a thorough and transparent pre-market review process: FDA needs to be transparent about both the review process and its enforcement of the regulations against those products and companies who are operating outside of the existing regulatory structure. This diligence is especially critical as the agency postponed its decisions on the pre-market reviews of the products that make up the largest share of the market. As the FDA continues its review process for these products, including JUUL, Vuse, blu, Logic, and NJOY, it must ensure a thorough and transparent process.
  • Restrict e-cigarette marketing to ensure it is aimed at adults: FDA must impose restrictions on all marketing, including social media marketing, to ensure e-cigarette advertising to be aimed at adults switching away from combustible tobacco.
  • Restrict access to adult smokers: FDA authorization of e-cigarettes should be accompanied by strict requirements that restrict access to adult smokers, including selling e-cigarettes in adult-only retail spaces, no self-service sales, and no in-store/window promotional signage near schools.
  • Internet sales: FDA should prohibit all non-face-to-face sales, along with internet sales of all tobacco products, including e-cigarettes.
  • Taxation: Federal, state and local tax-writing authorities should set taxes on e-cigarettes at a level sufficient to discourage youth use.
Girl looking out window
FDA should prohibit all non-face-to-face sales, along with internet sales of all tobacco products, including e-cigarettes.
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